Liver function damage and curability of occupational medicamentosa-like dermatitis induced by trichloroethylene: Cox regression analysis

Objective  To explore the potential effects of the liver function damage on the curability of occupational medicamentosa-like dermatitis induced by trichloroethylene (OMDT).

methods  The data of clinical courses and outcomes of the disease were collected from all 30 OMDT hospitalized patients from January 2012 to June 2016. The Cox regression was used to analyze the influence of minimums of serum total protein (TPL) and albumin (ALBL), and maximums of total bilirubin (TBILM), direct bilirubin (DBILM), alanine aminotransferase (ALTM), aspartate aminotransferase (ASTM), glutamyltranspeptidase (GGTM), and alkaline phosphatase (ALPM) on the curability of OMDT.

Results  The median of courses of disease for these 30 OMDT patients was 108 days, the censored outcome was 30.0%, and the cure rate was 70.0%. There was collinearity among various liver function damage indices and the principal component analysis was used to analysis these indices. After the first three principal components were included in the Cox regression the analysis showed that the first principal component reflecting the variations of TPL, ALBL, TBILM and DBILM significantly affected the curability of OMDT (RR=0.62, P < 0.05). The model expression obtained from the Cox regression showed that the curability of OMDT increased while TPL or ALBLincreased and TBILM, DBILM, ALTM, ASTM, GGTM or ALPMdecreased.

Conclusion  Liver function damage could affect the curability of OMDT, therefore actively protecting the liver function may help to improve the curability of the patients.