Assessment of effect of combined hemoperfusion and hemodialysis in treatment of acute paraquat poisoning: a meta-analysis

Objective To observe the therapeutic effect of combined hemoperfusion and hemodialysis in the treatment of acute paraquat poisoning.

Methods The papers related to therapy of acute paraquat poisoning with combined hemoperfusion and hemodialysis in the databanks, including CBMdisc, CNKI, CHKD, CSPD, CQVIP, PubMed and Embase databases in recently 16 years were searched.The available data was analyzed by the meta-analysis software of RevMan 5.3.

Results Finally 9 research papers were used among 317 searched papers.Totally 543 cases were reported, among which 308 cases were treated with combined hemodialysis and hemoperfusion and 235 cases were treated in routine way, and 90 death cases were reported in the treated group while 156 death cases reported in the routine treatment group.There was a good homogeneity of each study (χ²=5.96, DF=8, P>0.05, I²=0%).The combined OR of efficacy was 0.19(95% CI:0.13-0.28, Z=8.51, P < 0.01).

Conclusion The therapy of combined hemoperfusion and hemodialysis seems effective in the treatment of acute paraquat poisoning, but more data is needed to confirm such effects when a number of other confounding factors are controlled.