Objective To explore the predictive value of short-term prognosis in patients with non-ST-segment elevation myocardial infarction(NSTEMI) combined with GRACE score and neutrophil to lymphocyte ratio(NLR).
Methods A total of 628 patients with NSTEMI were studied, who underwent PCI treatment in our hospital from February 2015 to October 2019, of whom 529 cases without major adverse cardiovascular events (MACE) within 28 days after PCI were as non-MACE group, 99 cases with MACE as MACE group. The clinical data in the electronic medical record system were collected to analyze the impact of GRACE and NLR on the short-term prognosis of patients with NSTEMI.
Results Multivariate logistic regression analysis showed the following factors would be risk factors of MACE:the elder(OR=1.14, compared with patients aged ≤ 65); the NLR(OR=1.99, NLR ≥ 3.83 vs. NLR < 3.83); NT proBNP(OR=1.68, NT proBNP ≥ 478.83 ng/L vs. NT proBNP < 478.83 ng/L); the grace score (OR=2.53, low-risk vs. moderate and high risk); Killip grade (OR=1.73, Killip grade Ⅲ-Ⅳ vs. Killip grade Ⅰ-Ⅱ). ROC analysis showed that the AUC of prediction the MACE occurred within 28 days after PCI in NSTEMI patients by the NLR, GRACE scores and combination were 0.665 (95%CI:0.587-0.743), 0.782 (95%CI:0.718-0.847), 0.886 (95%CI:0.825-0.948), and the AUC of the prediction with combined indicators was higher than the single indicator (P < 0.05).
Conclusions GRACE score and NLR were the influence factors for short-term MACE in NSTEMI patients, and the combined indicators had a high predictive value for the occurrence of MACE within 28 days after PCI.
DownLoad: