Correlation between lymphocyte subsets and liver dysfunction among patients with dermatitis medicamentosa-like of Trichloroethylene

Objective The correlation between lymphocyte subsets and liver dysfunction among patients with dermatitis medicamentosa-like of trichloroethylene was evaluated to explore the pathogenesis of this disease. Methods A total of 32 patients were studied. Their lymphocyte subsets and liver function at hospitalization time were analyzed. Results The variation of lymphocyte subsets among the patients with different types of skin rashes had no significant difference (P>0.05); compared with reference values, the percentage of patients' mature T lymphocyte (CD3⁺) and CD8⁺T lymphocyte (CD3⁺CD8⁺) both increased significantly; the percentage of CD4⁺ T lymphocyte (CD3⁺ CD4⁺), NK cell(CD3-CD₁₆₊₅₆⁺),and B Lymphocyte subsets(CD19⁺) and CD4⁺/CD8⁺ all decreased significantly (P<0.01). There was a positive linear correlation between GTP and T lymphocyte (CD3⁺) and negative linear correlation between lymphocytes or CD3⁺ cells and cholinesterase or albumin. Conclusion The patients with dermatitis medicamentosa-like of trichloroethylene had disorder both of cellular and humoral immunity systems; there existed relationship between the liver dysfunction and this cellular immune system disorder.